This substance is found in a number of foods and in our bodies, and helps improve insulin sensitivity. Women with PCOS tend to be deficient in inositol, a deficiency linked to insulin resistance and subsequent anovulation and irregular cycles.Two types of inositol are recommended, D-chiro-inositol and myoinositol; both work very well together.

Dosing: The recommended dosage of myo-inositol and D-chiro-inositol is in a forty-to-one ratio, which is the ratio found in the body naturally, so 1,000 mg twice a day of myo-inositol plus 25 mg twice a day of D-chiro-inositol.

Scientific Research

• Poor responders undergoing intracytoplasmic sperm injection (ICSI) who received myo-inositol and folic acid supplementation experienced improved ovarian responses to gonadotropins, demonstrated by higher ovarian sensitivity index scores, as well as increased mature metaphase II oocytes rates and reduced total rec-FSH units compared to patients who received folic acid alone
• Supplementation of myo-inositol three months prior to follicular stimulation and in vitro insemination reduced the number of mature oocytes, improved total gonadotropin scores correlating with an increase in implantation rate, and subsequently reduced the total required dose of rFSH
• Myo-inositol supplementation decreased the number of immature oocytes and increased the number of oocytes recovered, embryos transferred, and follicular size to more than 15 mm at the time of ultrasound
• Myo-inositol or D-chiro-inositol supplementation increased the frequency of menstrual cycles and improved ovulation rate with or without metformin administration
• Myo-inositol improves sensitivity to clomiphene citrate, demonstrated by increased ovulation rates from 42% to 65.5% and pregnancy rates from 42.4% to 53.8% when compared to historical cohort
• Infertile PCOS patients undergoing intrauterine insemination (IUI) who received myo-inositol prior to controlled ovulation induction (COH) experienced less cancelled cycles and increased rates of pregnancy and number of spontaneous pregnancies, resulting in lower rFSH dose requirements and duration of ovulation induction

This substance is found in a number of foods and in our bodies, and helps improve insulin sensitivity.Two types of inositol are recommended, D-chiro-inositol and myo-inositol; both work very well together.

Studies show D-chiro-inositol is involved in proper insulin and glucose metabolism and may have a role in maintaining normal lipid profiles, cardiovascular function, and ovarian function. It may also help regulate inflammatory stress and modulate serotonin activity.

Dosing: The recommended dosage of myo-inositol and D-chiro-inositol is in a forty-to-one ratio, which is the ratio found in the body naturally, so 1,000 mg twice a day of myo-inositol plus 25 mg twice a day of D-chiro-inositol.

Berberine is a natural plant compound that has a profound impact on a critical enzyme called adenosine monophosphate-activated protein kinase or AMPK. AMPK is an enzyme that’s responsible for how energy is produced and used throughout the body. When AMPK is ineffective, this leads to a host of problems including hyperglycemia, lipid abnormalities, energy imbalances and eventually diabetes and metabolic syndrome.

There are only a handful of chemicals known to activate AMPK and berberine happens to be one of them. When AMPK is activated it triggers a breaking down of glucose causing a decrease in insulin resistance.

Berberine, which was first used in traditional Chinese medicine and ayurveda, has also been found to be helpful in reducing inflammation in the fatty tissues which also helps to both prevent and treat insulin resistance.

Dosing: The recommended dose is 500mg three times a day. Berberine should be used with caution in people who are taking other medications to treat diabetes, and people taking antibiotics should avoid taking berberine.