FERTILITY

I have created this protocol to help improve your ovarian function, egg quality and fertility. This will be helpful for consistent healthy ovulation which will improve your chances of getting pregnant. Please always take supplements with food.

xoxo

Order any of these supplements through the Period Portal Dispensary and get 15% off your entire purchase (US only).

For international users, you can order these through iHerb.com or Amazon.

THE PROTOCOL

Prenatal multivitamin

Prenatal multivitamin

Protocol for Life Balance

 

Dosing: Begin taking product at least 3 months prior to attempting to get pregnant and continue through pregnancy. If utilizing ART begin taking product at least 3 months prior to ovulation induction.

Scientific Research

  • Supplementation of multivitamin for 28 days prior to conception and though the second missed menstrual period positively increased fertility from 2.7% to 3.8%, measured by cumulative conceptions and multiple births, and reduced neural tube defects in women with or without ovarian stimulation
  • Subfertile women treated with clomiphene citrate and gonadotropins undergoing ovulation induction experienced higher pregnancy rates (66.7%) and required fewer pregnancy attempts with concomitant multiple micronutrient supplementation compared to folic acid alone (39.3%)
  • Micronutrient supplementation improved pregnancy rates and live birth rates when administered during in-vitro fertilization (IVF) therapy
N-acetylcysteine (NAC)

N-acetylcysteine (NAC)

Pure Encapsulations

NAC is the precursor to one of the body’s most potent antioxidants, glutathione. NAC has a wide variety of benefits, particularly liver detoxification support which will decrease inflammation and improve menstrual cycle problems and fertility. It has also been shown to support the reduction of endometriotic cysts (endometriosis located on the ovaries) and support fertility in women with endometriosis. Anecdotally, I’ve seen it improve pain in women with adenomyosis.

 

Dosing: 300mg twice a day (total of 600 mg a day) for 8-12 weeks. Or 600mg three times a day (total of 1800 mg a day) in patients with PCOS for 8-12 weeks.

Scientific research

  • NAC administered concomitantly in clomiphene citrate-resistant PCOS patients increased ovulation and pregnancy rates
  • When comparing clomiphene citrate treatment alone to concomitant treatment with NAC or metformin in PCOS patients, the group receiving NAC experienced higher rates of pregnancy (20% compared to 10% in the clomiphene citrate and clomiphene citrate/metformin groups), improved ovulation and peak endometrial thickness, and an increased number of ovulatory follicles larger than 18 mm
  • NAC administered with unilateral laparoscopic ovarian drilling (LOD) in clomiphene citrate-resistant PCOS patients increased ovulation rates from 67% to 87% and pregnancy rates from 57% to 77%, lowered miscarriage rates from 23.5% to 8.7%, and subsequently resulted in live birth rates of 67% compared to 40% in the placebo group
Vitamin D3

Vitamin D3

Pure Encapsulations

I often refer to vitamin D as the “period vitamin” because it plays such an important role in follicle development, follicle sensitivity to FSH, and progesterone production. Vitamin D has also been associated with helping to prevent Hashimoto’s. It is particularly important for anyone diagnosed with PCOS, because oftentimes it is deficient in that population.

 

Dosing: 1000 IU per day for 6 months or as directed by your doctor if your levels are low. 

Scientific Research

  • Repletion of vitamin D increases clinical pregnancy rates, the likelihood of positive pregnancy tests, and live birth rates in vitamin D-deficient individuals undergoing assisted reproductive technology (ART) when compared to a control group
  • Anti-Müllerian hormone (AMH) is regulated by vitamin D serum levels, demonstrated by a decrease in AMH after supplementation in PCOS patients and an increase in AMH after supplementation in healthy ovulatory women
  • Vitamin D3 led to improvements in menstrual cycle frequency in vitamin D-deficient women with PCOS
Ashwagandha

Ashwagandha

Pure Encapsulations

There have been over 200 studies done on this restorative, calming and nourishing herb. It’s great for people who have anxiety, nervousness, fatigue, have that tired but wired feeling, have problems falling asleep, and low thyroid function (low T3 or T4). It’s also amazing for people who have joint pain, fibromyalgia, muscle pain, and arthritis.

 

Dosing: 300 mg twice per day for 8-12 weeks.

Scientific Research

  • Ashwagandha supplementation enhanced sexual behavior in females, measured using the female sexual function index (FSFI) and female sexual distress index (FSDI)
  • Supplementation improved FSFI and FSDS scores, and increased number of sexual encounters
  • Ashwagandha supplementation improved sexual function, demonstrated by an increase in FSFI score by 122.67%, a total score accounting for improvements in arousal (62.09%), lubrication (59.30%), orgasm (82.05%), and satisfaction (62.33%) when compared to baseline
Myo-inositol

Myo-inositol

Protocol for Life Balance

 

This substance is found in a number of foods and in our bodies, and helps improve insulin sensitivity. Women with PCOS tend to be deficient in inositol, a deficiency linked to insulin resistance and subsequent anovulation and irregular cycles.Two types of inositol are recommended, D-chiro-inositol and myoinositol; both work very well together.

Dosing: The recommended dosage of myo-inositol and D-chiro-inositol is in a forty-to-one ratio, which is the ratio found in the body naturally, so 1,000 mg twice a day of myo-inositol plus 25 mg twice a day of D-chiro-inositol.

Scientific Research

  • Poor responders undergoing intracytoplasmic sperm injection (ICSI) who received myo-inositol and folic acid supplementation experienced improved ovarian responses to gonadotropins, demonstrated by higher ovarian sensitivity index scores, as well as increased mature metaphase II oocytes rates and reduced total rec-FSH units compared to patients who received folic acid alone
  • Supplementation of myo-inositol three months prior to follicular stimulation and in vitro insemination reduced the number of mature oocytes, improved total gonadotropin scores correlating with an increase in implantation rate, and subsequently reduced the total required dose of rFSH
  • Myo-inositol supplementation decreased the number of immature oocytes and increased the number of oocytes recovered, embryos transferred, and follicular size to more than 15 mm at the time of ultrasound
  • Myo-inositol or D-chiro-inositol supplementation increased the frequency of menstrual cycles and improved ovulation rate with or without metformin administration
  • Myo-inositol improves sensitivity to clomiphene citrate, demonstrated by increased ovulation rates from 42% to 65.5% and pregnancy rates from 42.4% to 53.8% when compared to historical cohort
  • Infertile PCOS patients undergoing intrauterine insemination (IUI) who received myo-inositol prior to controlled ovulation induction (COH) experienced less cancelled cycles and increased rates of pregnancy and number of spontaneous pregnancies, resulting in lower rFSH dose requirements and duration of ovulation induction
D-Chiro-Inositol

D-Chiro-Inositol

Klaire Labs

This substance is found in a number of foods and in our bodies, and helps improve insulin sensitivity.Two types of inositol are recommended, D-chiro-inositol and myo-inositol; both work very well together.

Studies show D-chiro-inositol is involved in proper insulin and glucose metabolism and may have a role in maintaining normal lipid profiles, cardiovascular function, and ovarian function. It may also help regulate inflammatory stress and modulate serotonin activity.

Dosing: The recommended dosage of myo-inositol and D-chiro-inositol is in a forty-to-one ratio, which is the ratio found in the body naturally, so 1,000 mg twice a day of myo-inositol plus 25 mg twice a day of D-chiro-inositol.

 

Medical Disclaimer

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Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.